학술논문
Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy.
Document Type
Article
Author
Source
Subject
*MICRORNA genetics
*DILATED cardiomyopathy
*GENE expression
*BIOMARKERS
*CHILDREN'S health
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Language
ISSN
1354-750X
Abstract
Context: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes. Objective: We aimed to determine miRNA expression levels in plasma of children with DCM. Materials and methods: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children. Results: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients. Discussion: miRNA level differences may provide the chance of using these miRNAs as new biomarkers. [ABSTRACT FROM PUBLISHER]