학술논문
PSMA imaging as a non-invasive tool to monitor inducible gene expression in vivo.
Document Type
Article
Author
Source
Subject
*GENE expression
*GENETIC vectors
*REPORTER genes
*PEPTIDASE
*FLUOROPOLYMERS
*CASTRATION-resistant prostate cancer
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Language
ISSN
2191-219X
Abstract
This article discusses a study that aimed to demonstrate the feasibility of using non-invasive imaging to monitor the expression of prostate-specific membrane antigen (PSMA) in vivo. The study used flow cytometry and PET-CT imaging to analyze PSMA expression in different clones of TRAMP-C2 cells before and after induction with doxycycline. The results showed a significant increase in radiotracer uptake after PSMA induction, confirming the potential of PSMA as a reporter gene for monitoring gene expression in vivo. The study suggests that this approach could be useful for improving the design of gene transfer methods and protocols in clinical research studies. [Extracted from the article]