학술논문
Synthesis, chemical structure elucidation, and biological studies on the effect of some vital metal ions on sulfadoxine.
Document Type
Article
Source
Subject
*CHEMICAL structure
*METAL ions
*LIGANDS (Chemistry)
*MICROCHEMISTRY
*THERMOGRAVIMETRY
*INFRARED spectra
*THERMAL analysis
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Language
ISSN
1070-3632
Abstract
Complexes of sulfadoxine as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III), and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The ligand can be coordinate as a bidentate feature via (C=N) and (S=O) groups. Sulfadoxine ligand as well as their complexes has been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, Δ H*, Δ S*, and Δ G* were estimated using Coats-Redfern as well as Horowitz-Metzger equations. [ABSTRACT FROM AUTHOR]