학술논문

Synthesis, chemical structure elucidation, and biological studies on the effect of some vital metal ions on sulfadoxine.
Document Type
Article
Source
Russian Journal of General Chemistry. Jan2015, Vol. 85 Issue 1, p176-184. 9p. 5 Diagrams, 6 Charts, 2 Graphs.
Subject
*CHEMICAL structure
*METAL ions
*LIGANDS (Chemistry)
*MICROCHEMISTRY
*THERMOGRAVIMETRY
*INFRARED spectra
*THERMAL analysis
Language
ISSN
1070-3632
Abstract
Complexes of sulfadoxine as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III), and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The ligand can be coordinate as a bidentate feature via (C=N) and (S=O) groups. Sulfadoxine ligand as well as their complexes has been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, Δ H*, Δ S*, and Δ G* were estimated using Coats-Redfern as well as Horowitz-Metzger equations. [ABSTRACT FROM AUTHOR]