학술논문
Three new α-pyrone derivatives from the plant endophytic fungus Penicillium ochrochloronthe and their antibacterial, antifungal, and cytotoxic activities.
Document Type
Article
Author
Source
Subject
*ADENOCARCINOMA
*ANTI-infective agents
*ANTIFUNGAL agents
*BREAST tumors
*CELL lines
*ANALYTICAL chemistry
*ANALYTICAL chemistry techniques
*COLON tumors
*FUNGI
*HEPATOCELLULAR carcinoma
*HETEROCYCLIC compounds
*LUNG tumors
*MICROBIAL sensitivity tests
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*RESEARCH funding
*PLANT roots
*SPECTROPHOTOMETERS
*SPECTRUM analysis
*STOMACH tumors
*YEW
*AUTOANALYZERS
EPITHELIAL cell tumors
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Language
ISSN
1028-6020
Abstract
Three new 3,4,6-trisubstituted α-pyrone derivatives, namely 6-(2′R-hydroxy-3′E,5′E-diene-1′-heptyl)-4-hydroxy-3-methyl-2H-pyran-2-one (1), 6-(2′S-hydroxy-5′E-ene-1′-heptyl)-4-hydroxy-3-methyl-2H-pyran-2-one (2), and 6-(2′S-hydroxy-1′-heptyl)-4 -hydroxy-3-methyl-2H-pyran-2-one (3), together with one known compound trichodermic acid (4), were isolated from the solid-substrate fermentation culture of Penicillium ochrochloronthe associated the roots of Taxus media. Compounds 1–4 displayed the antimicrobial activity selectively against tested fungal and bacterial strains with minimum inhibitory concentration (MIC) values ranging from 12.5 to 100 μg/ml. Furthermore, we found that only compound 4 exhibited moderate cytotoxicity against five human cancer cells (A549, LN229, MGC, LOVO, and MDA231) with IC50 values of 51.45, 23.43, 39.16, 46.97, and 42.85 μg/ml, respectively. [ABSTRACT FROM AUTHOR]