학술논문
Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases: results from a randomized trial in ovarian cancer.
Document Type
Article
Author
Demuytere, Jesse; Carlier, Charlotte; Van Helden, Tom; Belza, Joke; Vanhaecke, Frank; Xie, Feifan; Vermeulen, An; Weerts, Joseph; Thomale, Jürgen; Denys, Hannelore; Tummers, Philippe; Van Kerschaver, Olivier; Willaert, Wouter; Cosyns, Sarah; Merseburger, Peter; Claeys, Arne; Van den Eynden, Jimmy; Ceelen, Wim
Source
Subject
*GENE expression
*CISPLATIN
*OVARIAN cancer
*LASER ablation inductively coupled plasma mass spectrometry
*OVARIAN epithelial cancer
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Language
ISSN
0007-1323
Abstract
This article explores the impact of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases in ovarian cancer patients. The study examines the effects of hyperthermic intraperitoneal chemoperfusion (HIPEC) with cisplatin on pharmacokinetics, cellular responses, and gene expression. The findings reveal that platinum penetration in tumor tissue varies, with limited uptake after 90 minutes. Hyperthermia triggers a heat shock response in cancer cells and may accelerate the clearance of platinum in the peritoneum. The article provides a comprehensive overview of the study's design, procedure, and statistical analysis. Additionally, it discusses the effects of hyperthermia and HIPEC on the peritoneal and tumor immune contexture in women with recurrent ovarian cancer. The study suggests that hyperthermia enhances the systemic absorption of cisplatin and potentially improves tissue penetration in ovarian cancer. It also induces a heat shock response and up-regulates genes associated with cellular shock. However, further research is necessary to confirm the anticancer effects of hyperthermia. The study was funded by the Flemish Cancer Foundation, and the authors disclose no conflicts of interest. [Extracted from the article]