학술논문
Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study.
Document Type
Article
Author
Phanuphak, Nittaya; Teeraananchai, Sirinya; Hansudewechakul, Rawiwan; Gatechompol, Sivaporn; Chokephaibulkit, Kulkanya; Hanh Le Dung Dang; Dan Ngoc Hanh Tran; Achalapong, Jullapong; Teeratakulpisarn, Nipat; Chalermchockcharoenkit, Amphan; Thamkhantho, Manopchai; Pankam, Tippawan; Singtoroj, Thida; Termrungruanglert, Wichai; Chaithongwongwatthana, Surasith; Kerr, Stephen J.; Sohn, Annette H.
Source
Subject
Language
ISSN
1058-4838
Abstract
Background. Female youth with perinatally acquired human immunodeficiency virus (PHIV) may be at higher risk than uninfected youth for persistent anogenital human papillomavirus (HPV) infection, due to prolonged immunodeficiency. Methods. A 3-year cohort study was conducted between 2013 and 2017 among Thai and Vietnamese PHIV and HIV-uninfected females 12-24 years, matched by age group and number of lifetime sexual partners. For HPV genotyping, cervical and anal samples were obtained at baseline and annually. Vaginal samples were collected at baseline and every 6 months. Factors associated with highrisk HPV (HR-HPV) persistence and incidence were assessed. Results. We enrolled 93 PHIV and 99 HIV-uninfected females. MediIQRage was 19 (interquartile range [IQRnonavalent years. For the 7 HR-HPV types (16, 18, 31, 33, 45, 52, 58) in thnonavalentnt HPV vaccine, PHIV had significantly higher incidence (aHR .03) and persistence (P = .01) than HIV-uninfected youth over a 3-year period. aHRing HIV (adjusted hazard ratioaHRHR] 2.1, 95% confidence interval [CI] 1.1-3.9) aaPRever using illegal substancesaHRspan class="aPRllUnderlinedText">aHR 4.8, 95% CI 1.8-13.0) were associataPRwiaPRiaPRdent 7 HR-HPV infections. HIV-paPRtive saPRuaPRadjusted prevalence ratio [aPR] 2.2, 95% CI 1.5-3.2), recentaPRcaPRl use (aPR 1.75, 95% CI 1.2-2.5), anaPRiaPRr number of lifetime partners (aPR 2.0, 95% CI 1.4-3.1, for 3-5 partners; aPR 1.93, 95% CI 1.2-3.2, for ≥6 partners) were significantly associated with persistent 7 HR-HPV infections. Conclusions. Female PHIV were at higher risk of having anogenital HR-HPV acquisition and persistence. Primary and secondary prevention programs for HPV infection and HPV-related diseases should be prioritized for PHIV children and youth. [ABSTRACT FROM AUTHOR]