학술논문
Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring
Document Type
Article
Author
Source
Subject
*OVARIAN tumors
*CARCINOGENESIS
*CHRYSENE
*TARGETED drug delivery
*DISEASE susceptibility
*LABORATORY mice
*TUMOR treatment
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Language
ISSN
0304-3835
Abstract
Abstract: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [14C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [14C] 3weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens. [Copyright &y& Elsevier]