부산대학교 도서관

Background: To estimate the prevalence of posterior segment eye lesions and to identify their ocular and systemic associations within the Gutenberg Health Study (GHS) in Germany. Methods: Assessment and grading of fundus images as well as physical examination and history taking were performed in the cross-sectional analysis of 15,010 subjects (aged 35–74 years) using standardised procedures to determine the prevalence and associations of various posterior segment eye lesions. Results: Fundus photographs of both eyes were available for 12,782 (85.2%; 50% female) subjects. The prevalence weighted to the region of Mainz and Mainz-Bingen in Germany was for choroidal nevi 2.4%, drusen of the optic nerve head 0.2%, tilted discs 1.5%, chorioretinal scars suggestive of toxoplasmosis 0.2%, retinitis pigmentosa 0.04% and persistent hyaloid artery 0.02%. Choroidal nevi were positively associated with a history of myocardial infarction (OR = 2.7, 95% confidence interval 1.2–6.2, p value = 0.017). Tilted discs were positively associated with increased intraocular pressure (OR = 1.09 per mm Hg (1.02–1.16), p = 0.011) and negatively associated with smoking (OR 0.4 (0.3–0.7), p = 0.0022). Participants with tilted discs had a mean spherical equivalent of − 3.6 dioptres (standard deviation 4.0) compared with − 0.4 dioptres (2.4) to those without. Conclusion: Our study is—to the best of our knowledge—the first to determine the prevalence of drusen of optic nerve head among Caucasians, to show a positive association between tilted discs and increased intraocular pressure and questions a possible link between choroidal nevi and myocardial infarction. It also showed that participants with tilted discs had a lower mean spherical equivalent than those without. [ABSTRACT FROM AUTHOR]