학술논문

Novel Targeted Agents in Hodgkin and Non-Hodgkin Lymphoma Therapy.
Document Type
Article
Source
Pharmaceuticals (14248247). Sep2015, Vol. 8 Issue 3, p607-636. 30p.
Subject
*LYMPHOMA treatment
*HODGKIN'S disease treatment
*ANTIBODY-drug conjugates
*CELL surface antigens
*CANCER chemotherapy
*IMMUNOREGULATION
*MONOCLONAL antibodies
*THERAPEUTICS
Language
ISSN
1424-8247
Abstract
There has been a recent emergence of novel targeted agents for treatment of Hodgkin and non-Hodgkin lymphoma. In particular, antibodies and antibody-drug conjugates directed against surface antigens, agents that block immune checkpoint pathways, and small molecule inhibitors directed against cell signaling pathways have shown significant promise in patients with relapsed and refractory disease and in the frontline setting. With the development of these new therapies, cytotoxic chemotherapy may be avoided entirely in some clinical settings. This review will present the latest information on these novel treatments in Hodgkin and non-Hodgkin lymphoma and will discuss both recently approved agents as well as drugs currently being studied in clinical trials. [ABSTRACT FROM AUTHOR]