부산대학교 도서관

Despitethe prevalence of head-to-side chain threonine linkagesin natural products, their incorporation has been underexplored insynthetic cyclic peptides. Herein we investigate a cyclic peptidescaffold able to undergo an N–Oacyl rearrangement. Upon acylation of the amine with diverse carboxylicacids, the resulting cyclic depsipeptides displayed favorable cellularpermeability and a conformation similar to the parent peptide. Therearrangement was found to be scaffold and conformation dependentas evidenced by molecular dynamics experiments. [ABSTRACT FROM AUTHOR]