학술논문
Illness Severity in Hospitalized Influenza Patients by Virus Type and Subtype, Spain, 2010-2017.
Document Type
Journal Article
Author
Source
Subject
*INFLUENZA
*INFLUENZA A virus
*HOSPITAL patients
*ADULT respiratory distress syndrome
*INTENSIVE care units
*INFLUENZA epidemiology
*AGE distribution
*RETROSPECTIVE studies
*SEVERITY of illness index
*HOSPITAL care
*INFLUENZA A virus, H1N1 subtype
*INFLUENZA A virus, H3N2 subtype
*LONGITUDINAL method
ADMISSION & discharge
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Language
ISSN
1080-6040
Abstract
We conducted a retrospective cohort study to assess the effect of influenza virus type and subtype on disease severity among hospitalized influenza patients in Spain. We analyzed the cases of 8,985 laboratory-confirmed case-patients hospitalized for severe influenza by using data from a national surveillance system for the period 2010-2017. Hospitalized patients with influenza A(H1N1)pdm09 virus were significantly younger, more frequently had class III obesity, and had a higher risk for pneumonia or acute respiratory distress syndrome than patients infected with influenza A(H3N2) or B (p<0.05). Hospitalized patients with influenza A(H1N1)pdm09 also had a higher risk for intensive care unit admission, death, or both than patients with influenza A(H3N2) or B, independent of other factors. Determining the patterns of influenza-associated severity and how they might differ by virus type and subtype can help guide planning and implementation of adequate control and preventive measures during influenza epidemics. [ABSTRACT FROM AUTHOR]