학술논문
IMMUNOGLOBULIN M-ENRICHED INTRAVENOUS POLYCLONAL IMMUNOGLOBULINS REDUCE BACTEREMIA FOLLOWING KLEBSIELLA PNEUMONIAE INFECTION IN AN ACUTE RESPIRATORY DISTRESS SYNDROME RAT MODEL.
Document Type
Article
Author
Source
Subject
*BRONCHOALVEOLAR lavage
*KLEBSIELLA pneumoniae
*BACTEREMIA
*GLOBIN
*IMMUNOGLOBULINS
*ARTIFICIAL respiration
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Language
ISSN
0190-2148
Abstract
Mechanical ventilation is known to induce bacterial translocation from the lung into the systemic circulation. This study determined the effect of immunoglobulin M (IgM)-enriched polyclonal immunoglobulins on bacteremia due to ventilation-induced translocation in an acute respiratory distress syndrome (ARDS) rat model with Klebsiella-induced pneumonia. After whole lung lavage, SpragueDawley rats intravenously received either a high dose or a low dose of an immunoglobulin preparation, or an albumin solution as control, followed by an intratracheal injection of a Klebsiella pneumoniae solution. Blood colony-forming units (CFUs) in the treatment groups were significantly lower during the 3-hour ventilation period compared to the control group. The authors conclude that IgM-enriched polyclonal immunoglobulins lead to a reduction of bacteria in blood of surfactant-deficient, ventilated rats infected with Klebsiella pneumoniae. [ABSTRACT FROM AUTHOR]