학술논문
Controlled Exposure to Diesel Exhaust Causes Increased Nitrite in Exhaled Breath Condensate Among Subjects With Asthma.
Document Type
Article
Author
Source
Subject
*AIR pollution
*ASTHMA
*CROSSOVER trials
*GENES
*RESEARCH funding
*PULMONARY function tests
*CONTINUING medical education
*ENVIRONMENTAL exposure
*OXIDATIVE stress
*RANDOMIZED controlled trials
*BLIND experiment
*DATA analysis software
*DESCRIPTIVE statistics
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Language
ISSN
1076-2752
Abstract
The article describes a study that determined if oxidative/nitrosative stress played a role in the acute effects of diesel exhaust (DE) on subjects with asthma. Results showed that, after exposure to DE, subjects with asthma displayed increased airway hyperreactivity and obstruction. Increased nitrite in exhaled breath condensate, in the absence of increased exhaled nitiric oxide, indicates a noninflammatory oxidative stress mechanism by which DE affects the lung.