학술논문

Antimicrobial Peptides, a Pool for Novel Cell Penetrating Peptides Development and Vice Versa.
Document Type
Article
Source
International Journal of Peptide Research & Therapeutics. Jun2021, Vol. 27 Issue 2, p1205-1220. 16p.
Subject
*ANTIMICROBIAL peptides
*PEPTIDES
*PEPTIDE antibiotics
Language
ISSN
1573-3149
Abstract
Membrane active peptides are a family of peptides with ability to interact with plasma membrane. Cell penetrating peptides (CPPs) interact with membrane and enter cells via different pathways without damaging the membrane. Antimicrobial peptides (AMPs) are peptides active against microorganisms. Both CPPs and AMPs belong to membrane active peptides family. AMPs interact with membrane and some are able to translocate into cells without the need of permanent permeabilization. Thus they have can be promising source of CPPs. Moreover, some CPPs have shown antimicrobial activity against pathogens. In this review we summarize the studies with the aim of developing functional and efficient CPPs and AMPs from existing and known peptide pool. [ABSTRACT FROM AUTHOR]