학술논문
Transcriptional Dysregulation of Adipose Tissue Autophagy in Obesity.
Document Type
Article
Author
Source
Subject
*OBESITY genetics
*GENE regulatory networks
*ADIPOSE tissues
*AUTOPHAGY
*HUMAN genetic variation
*GENE expression
*
*
*
*
*
Language
ISSN
1548-9213
Abstract
There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity. [ABSTRACT FROM AUTHOR]