부산대학교 도서관

Conventionally viewed as energy storage depots, lipid droplets (LDs) play a central role in muscle lipid metabolism and intracellular signaling, as recognized by recent advances in our biological understanding. Specific subpopulations of muscle LDs, defined by location and associated proteins, are responsible for distinct biological functions. In this review, the traditional view of muscle LDs is examined, and the emerging role of LDs in intracellular signaling is highlighted. The effects of chronic and acute exercise on muscle LD metabolism and signaling is discussed. In conclusion, future directions for muscle LD research are identified. The primary focus will be on human studies, with inclusion of select animal/cellular/non-muscle studies as appropriate, to provide the underlying mechanisms driving the observed findings. In a skeletal muscle context, microenvironments comprised of fiber type and region within the myofiber, result in lipid droplet (LD) compartmentalization. Acute and chronic exercise can differentially alter muscle LD stores within compartments, and promote mitochondrial-LD interactions, but the exercise-induced effects may depend on metabolic status. Traditionally viewed as an energy storage organelle, the LD also functions as a critical signaling node, involved in regulating transcriptional programs affiliated with mitochondrial biogenesis, and fatty acid (FA) oxidation. [ABSTRACT FROM AUTHOR]