부산대학교 도서관

Slow oscillations of cytosolic calcium ion concentration -- typically originate from release by intracellular stores, but in some cell types can be triggered and sustained by Ca2+ influx as well. In this study we simultaneously monitored changes inand in the electrical activity of the cell membrane by combining indo-1 and patch-clamp measurements in single rat chromaffin cells. By this approach we observed a novel type of spontaneousoscillations, much faster than those previously described in these cells. These oscillations are triggered and sustained by complex electrical activity (slow action potentials and spike bursts), require Ca2+ influx and do not involve release from intracellular stores. The possible physiological implications of this new pathway of intracellular signalling are discussed. [ABSTRACT FROM AUTHOR]