학술논문
Interaction with DNA as a cytotoxicity factor of a novel glycoside derivative of indolocarbazole.
Document Type
Article
Author
Source
Subject
*CARBAZOLE
*DNA
*ABSORPTION
*ATMOSPHERIC temperature
*LIGAND binding (Biochemistry)
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Language
ISSN
1607-6729
Abstract
The article focuses on the interaction of glycosylated derivatives of indolocarbazole with DNA. The adsorption isotherm of pyrrolo 3,4-c carbazole-5,7-dione (AK-1006) molecules on DNA has two absorption maxima at 285 and 320 nanometer. The adsorption isotherms for AK-1006 complexes on DNA signifies that all molecules of bound ligand are intercalated into the double helix. Gene activation has decreased at high concentration using the DNA-binding compounds such as cytosar.