학술논문
Intravenous paracetamol toxicity in a malnourished child.
Document Type
Article
Source
Subject
*ACETAMINOPHEN
*DRUG overdose
*MALNUTRITION in children
*HEPATOTOXICOLOGY
*ALANINE aminotransferase
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Language
ISSN
1556-3650
Abstract
We present a case of intravenous (IV) paracetamol overdose in a nutritionally malnourished child during hospital admission. A ten-fold IV paracetamol dosing error ocurred, with delayed recognition and treatment resulting in transient hepatotoxicity, with a peak alanine transaminase (ALT) of 1378 IU/L in a 3-year-old child. Our case suggests that hepatotoxicity may occur for lower doses of IV paracetamol compared to oral ingestion, especially in the malnourished, and that a dose less than 150 mg/kg of IV paracetamol should be used to define treatment following overdose in a child with potential nutritional deficiencies. [ABSTRACT FROM AUTHOR]