학술논문
Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging.
Document Type
Article
Source
Subject
*MITOCHONDRIAL DNA
*GENETIC mutation
*PHENOTYPES
*GENOMES
*MITOCHONDRIA
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Language
ISSN
1474-9718
Abstract
Discusses whether age-related mitochondrial DNA (mtDNA) mutations accumulate to levels of physiological relevance and whether they are associated with age-related phenotypes. Information on the mitochondrial genome; Effect of high levels of mtDNA mutations; Age-associated mtDNA deletion mutations; Implication of the link between mitochondrial genomic alterations and fibre atrophy and breakage.