부산대학교 도서관

A well-characterised example of a complete self-regulated inflammatory pathway is the interleukin-1 (IL-1) system comprising the agonist cytokines IL-1 and IL-1 , and their receptor IL-1R1 (IL-1 receptor type I), which is inhibited by the IL-1 receptor antagonist IL-1Ra.1 A related system involves the three IL-36 cytokines IL-36 , IL-36 and IL-36 , which are neutralised when the IL-36Ra binds the IL-36 receptor IL-1RL2 (also known as IL-36R). In agreement with this, histological analyses of epidermal and dermal thickness did not reveal statistically significant differences between wild-type and IL-36 -, IL-36 - or IL-36 -deficient mice (Figure 1C-D). Hence, we also evaluated expression levels of a number of cytokines linked to the disease phenotype6 and previously shown to be regulated by IL-36 directly or indirectly.1 Inflammation was clearly induced in all four strains, as chemokines not measurable in normal ears were readily detected after DNFB treatment. [Extracted from the article]