학술논문
A catalytic DNA circuit-programmed and enzyme-powered autonomous DNA machine for nucleic acid detection.
Document Type
Article
Author
Source
Subject
*DEOXYRIBOZYMES
*NUCLEIC acids
*DNA
*DNA probes
*ENDONUCLEASES
*ACID analysis
*SINGLE-stranded DNA
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Language
ISSN
0003-2654
Abstract
A catalytic DNA circuit was ingeniously engineered to harness the cleavage of a nicking endonuclease on a triple-stranded duplex DNA probe, autonomously actuating a successive enzyme-powered DNA machine for one-step, isothermal, and autocatalytic nucleic acid analysis. The detection performance could be tuned with or without the use of enzymes. [ABSTRACT FROM AUTHOR]