학술논문
Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus Metapochonia lutea.
Document Type
Article
Author
Source
Subject
*FILAMENTOUS fungi
*MICROBIAL metabolites
*YEAST fungi
*MICROFUNGI
*GRAM-negative bacteria
*HIGH performance liquid chromatography
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Language
ISSN
1420-3049
Abstract
In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi). [ABSTRACT FROM AUTHOR]