학술논문
‘Closing the loop’ in biological systems modeling — From the in silico to the in vitro
Document Type
Article
Author
Source
Subject
*SYSTEMS biology
*MATHEMATICAL models
*METHODOLOGY
*MATHEMATICAL optimization
*CONTROL theory (Engineering)
*EXPERIMENTAL design
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Language
ISSN
0005-1098
Abstract
Abstract: This work presents a holistic ‘closed loop’ approach for the development of models of biological systems. The ever-increasing availability of experimental information necessitates the advancement of a systematic methodology to organise and utilise these data. Herein, we present a biological model building framework that maps the treatment of the information from the initial conception of the model, through its experimental validation and finally to its application in model-based optimisation studies. We highlight and discuss current issues associated with the development of mathematical models of biological systems and share our perspective towards a holistic ‘closed loop’ approach that will facilitate the control of the in vitro through the in silico. [Copyright &y& Elsevier]