부산대학교 도서관

Introduction: Exacerbated postprandial lipemia (ePPL) is considered as an emergent risk factor related with cardiovascular disease (CVD). Several factors among which stand out diet composition and genetic background modulate ePPL. Hypothesis: Our aim was to explore whether apolipoprotein E (apoE) single nucleotide polymorphisms (SNPs), widely related with lipid metabolism, interact with two healthy dietary patterns (low-fat diet (LF-diet) diet versus Mediterranean diet (MedDiet)) modulating ePPL in coronary heart disease (CHD) patients. Methods: We selected patients from the CORDIOPREV study who underwent oral fat load tests (FLT) at baseline and the three years follow up (N = 506). Subjects were randomized to either a LF-diet (<30% fat (12-14 % monounsaturated fatty acids (MUFA)) or a MedDiet (35% fat (22% MUFA)). Lipids in serial blood drawn at 0, 1, 2, 3 and 4 hours after the FLT and single nucleotide polymorphisms (SNPs) of the apoE gene locus (rs439401, rs440446 and rs7412) were determined. Results: After three years of follow-up, we found a gene-diet interaction between apoE rs439401 SNP and MedDiet. Specifically, T-allele carriers in MedDiet group, showed a greater decrease in postprandial triglycerides (TG) plasma concentrations (p = 0.03) and postprandial chylomicrons (Qm) plasma concentrations (p = 0.01) compared with CC subjects. Consistently, the area under the curve of TG (AUC-TG; p -interaction = 0.03) and AUC-Qm (p -interaction = 0.02) was significantly lower in T-allele carriers compared with CC subjects. Conclusions: These results show how MedDiet modulates ePPL through genetic background in CHD patients. Understanding step by step these gene-diet interactions may be a right strategy for a specific dietary advice in these patients. [ABSTRACT FROM AUTHOR]