학술논문
T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers.
Document Type
Article
Author
Source
Subject
*T cells
*LYMPHOCYTES
*HIV infections
*HIV-positive persons
*LENTIVIRUS diseases
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*
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Language
ISSN
1742-6405
Abstract
Background: Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment. Methods: Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. We assessed immune activation by measuring the percent of CD38+HLA-DR+CD8+ T cells in the EC group and comparing it with that in 24 treatment-naïve HIV disease progressors and 13 HIV uninfected healthy controls. Results: Compared to HIV uninfected subjects, EC had higher percentages of CD38+HLA-DR+CD8+ T cells (p < 0.001) that was lower than that observed in progressors (p < 0.01). Fifteen of 25 EC had a slope of CD4 count change that was not significantly different from 0 while 3 had a positive and 7 a negative CD4 count slope. Immune activation did not distinguish EC subsets with stable/increasing versus declining CD4 counts. Conclusions: Elevated immune activation in ECs is not associated with a faster rate of CD4 decline [ABSTRACT FROM AUTHOR]