부산대학교 도서관

About 1 in 8 women will develop breast cancer during their lifetime, and as treatments have progressed, cancer survivorship has continued to improve. Breast cancer survivors treated with doxorubicin (DOX) based chemotherapy are at increased risk for developing cardiomyopathies and heart failure. Exercise preconditioning has been shown to mitigate DOX toxicity in animal models, but its value in humans remains unknown. Measurements of cardiac function, such as ejection fraction (EF) and left ventricular global longitudinal strain (LVGLS), have been shown to be predictive of mortality risk. PURPOSE: To test the hypothesis that HIIE preconditioning and exercise continued throughout treatment can be used to prevent the decline in EF and LVGLS in women treated with dosedense DOX chemotherapy. Here, we present preliminary data from the first 8 participants (HIIE n=5, Control n=3). METHODS: Breast cancer patients (n=8; 50±10y; 168±4cm; 94±35kg; 32.6±11.5 BMI) who were scheduled to undergo dose-dense chemotherapy were randomized into one of two interventions i) control (physical activity advice) or ii) exercise preconditioning (3 days/week supervised exercise). Baseline testing occurred 1-2 weeks prior to the start of DOX treatment while interventions started 1 week prior to treatment and continued throughout DOX treatment (4 doses with bi-weekly dosing). Post testing occurred within 3-7 days after the last DOX treatment. Deltas from between group differences were analyzed using independent samples t-tests. RESULTS: A reduction in EF was observed in control versus HIIE (-4.3±6.5 vs. 2.0±3.2% respectively; p=0.11, d=1.17). Similarly, there was reduced LVGLS in the control group while the HIIE group saw improvement (2± 0.0% vs. -1.2±2.6% respectively; p= 0.05, d= 1.21). Measures of physical function showed the control group had a decrease in peak power output versus HIIE (-8.3±5.7 vs. 1.4±14.9 Watts respectively; p=0.33,d=0.76) and in VO2peak (-0.21±0.03 vs. -0.02±0.09 L/min respectively; p=0.02, d= 1.52). CONCLUSION: These preliminary data show that HIIE preconditioning prior to DOX based chemotherapy may serve as a strategy to preserve both cardiac and physical function in breast cancer patients undergoing dose-dense DOX chemotherapy. Funding: Virginia Piper Foundation, ASU, Mayo Clinic Arizona, and UACC [ABSTRACT FROM AUTHOR]