학술논문
Three new diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii.
Document Type
Article
Author
Source
Subject
*ANTIBIOTICS
*CHROMATOGRAPHIC analysis
*CRITICALLY ill
*FERMENTATION
*FUNGI
*MASS spectrometry
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*PATIENTS
*RESEARCH funding
*STAPHYLOCOCCAL diseases
*PHENYL ethers
*METHICILLIN-resistant staphylococcus aureus
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
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Language
ISSN
1028-6020
Abstract
Three new diphenyl ethers (1-3), together with four known isopentylated diphenyl ethers derivatives (4-7), were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-3 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed strong inhibitions with inhibition zone diameters (IZD) of 20.2 ± 2.5 mm and 17.9 ± 2.2 mm, respectively. Compound 3 also showed good inhibition with IZD 15.2 ± 1.8 mm. The IZD data of compound 1 is close to that of positive control with IZD 21.9 ± 2.1 mm. [ABSTRACT FROM AUTHOR]