부산대학교 도서관

The interleukin-1 receptor antagonist (IL-1RA) cytokine is thought to counteract tumor angiogenesis/metastasis. Two single nucleotide polymorphisms in the IL-1RA gene (rs4251961 T/C and rs579543 C/T) influence IL-1RA circulating levels with highest production in carriers of the homozygous rs4251961 T/T and rs579543 T/T genotypes. A total of 180 patients with metastatic colorectal cancer were categorized as high IL-1RA producers if they were carriers of at least one of the rs4251961 T/T or rs579543 T/T genotypes (T/T carriers). Median survival times were 35.8 months (95% confidence interval: 29.7–43.7 months) and 28.6 months (95% confidence interval: 25.6–30 months) in 56 T/T carriers and in 124 non-T/T carriers, respectively. The favorable association between T/T carriers’ status and survival was significant in the multivariate analysis (P=0.018). Also, T/T carriers and non-T/T carriers were prevalent among patients with Karnofsky performance status 90–100 and 70–80, respectively (P=0.002). These findings encourage additional studies in this field and the evaluation of a recombinant-IL-1RA for anticancer activity.The Pharmacogenomics Journal (2009) 9, 78–84; doi:10.1038/tpj.2008.16; published online 23 December 2008 [ABSTRACT FROM AUTHOR]