부산대학교 도서관

The article presents a study which describes a distal gene of the locus associated in the virulence of Listeria monocytogenes. The study found that the novel gene lmo1273 could complement an Escherichia coli rnhA-rnhB thermosensitive growth phenotype and that it encodes functional RNase H. Kinetic studies in infected mice showed impaired multiplication of the lmo1273 mutant in target organs and inactivation of the gene stimulated strong attenuation of virulence. Moreover, microarray analyses of an lmo1273-overexpressing strain compared to wild-type strain suggest a pleiotropic regulatory role of lmo1273 and possible association with amino acid uptake.