학술논문
Association of leukemia and mitochondrial diseases—A review.
Document Type
Article
Author
Source
Subject
*OXIDATIVE phosphorylation
*LEUKEMIA
*FREE radicals
*MITOCHONDRIAL DNA
*GENETICS
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Language
ISSN
2249-4863
Abstract
Mitochondria play an important role in various metabolic pathways like oxidative phosphorylation free radical generation and apoptosis. Defects in mitochondrial function are responsible for a number of heterogenous clinical presentations along with development and progression of cancer. Decrease in cellular energy (ATP) production because of impaired oxidative phosphorylation is the most important cause for these underlying disorders. The present review article aims to provide current understanding of mitochondrial genetics and biology and relates the mt-DNA alterations in leukemia patients. [ABSTRACT FROM AUTHOR]