학술논문
Challenges in the Diagnosis of Beta-thalassemia Syndrome: The Importance of Molecular Diagnosis.
Document Type
Article
Author
Source
Subject
*PHYSICAL diagnosis
*MOLECULAR diagnosis
*GENETIC mutation
*RETICULOCYTES
*BLOOD transfusion
*LABORATORIES
*ANEMIA
*BLOOD diseases
*BETA-Thalassemia
*PHENOTYPES
*
*
*
*
*
*
*
*
*
Language
ISSN
1999-768X
Abstract
Patients with heterozygous β-thalassemia are generally asymptomatic. However, the intermediate phenotype is uncommon, and patients require further investigation to confirm the diagnosis. We describe a 32-year-old woman (gravida 3, para 2) with heterozygous β-thalassemia who presented with symptomatic anemia and had a history offrequent blood transfusion in each pregnancy. Physical examination was unremarkable. Laboratory results at presentation showed hypochromic microcytic anemia with reticulocytosis. Molecular study revealed intermedia phenotypes resulting from coinheritance of heterozygous β-globin chain mutation (IVS1-5) and a rare heterozygous α-globin triplication (αααanti-3.7). In this case report, we discuss the laboratory diagnostic approaches and the challenges faced in investigating this case. [ABSTRACT FROM AUTHOR]