부산대학교 도서관

The anti-ulcerogenic activity of fresh fruit juice of Emblica officinalis and its methnol extract were evaluated in absolute ethanol-, indomethacin-and histamine-induced experimen-tal ulcers in rats. Gastric ulcers inducedby oral administration of absolute ethanol (5 ml/kg) to fasted rats were reduceddose-dependently by oral pretreatment of animals with either E. officinalis fruit juice or its methanol extract (25–100 mg/kg). Ethanol administrationcaused severe gastric damage with an ulcer index of 4.6 ± 0.5, a 44%reduction in glutathione (GSH) content of gastric mucosa, an increase in stomachweight due to inflammation (1.24 ± 0.12 g/100 g body weight), intraluminalbleeding (100%), and increased mortality rate (44%). E. officinalis fresh fruit juice administration (50 mg/kg) 30 min before alcohol challenge,reduced the ulcer index to 1.8 ± 0.7, limited the depletion of GSHto 15.2%, reduced the stomach weight to 0.75 ± 0.12 g/100 g body weight,and afforded 100% protection against mortality and intraluminal bleeding.Administration of indomethacin (25 mg/kg) and histamine (10 mg/kg) increasedthe ulcer index to 2.2 ± 0.7 and 1.8 ± 0.7 respectively, anda 28.5 and 20.6% depletion in mucosal GSH, respectively, as compared to normalrats. E. officinalis administration showed a dose-dependent protectiveeffect against gastric damage induced by indomethacin and histamine. The protectionafforded by E. officinalis fruits was found to be better than thatof ranitidine (50 mg/kg). The results of the present study suggested the novelcytoprotective activity of E. officinalis fruits on gastric mucosalcells. [ABSTRACT FROM AUTHOR]