학술논문
IN VITRO RELEASE STUDIES OF ALENDRONATE FROM HA-AL COMPOSITE DEPOSITED ON TITANIUM METAL SUBSTRATE.
Document Type
Article
Author
Source
Subject
*ALENDRONATE
*METALLIC composites
*METALLIC surfaces
*METALS
*CHEMICAL species
*BONE diseases
*TITANIUM composites
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Language
ISSN
1844-9581
Abstract
Bisphosphonates are medicines used to inhibit osteoclastic activity in a number of bone diseases (Paget's disease, osteoporosis, hypercalcemia, primary and secondary hyperparathyroidism, bone metastases). Following in vitro release studies, crystalline hydroxyapatite (HA) was found to be a stable phase in contact with the release medium, and alendronate (AL) bound to HA by the synthesis process was slowly released from the metallic component (titanium) into the release medium for 10 days. Hydroxyapatite after implantation produces chemical species that support the adhesion of the implant to the surrounding tissue forming a functional connective structure. Thus synthesis of the HA-AL composite can be considered as a viable solution for the inclusion of bisphosphonate on the surface of metallic prosthetic components used in orthopedics. [ABSTRACT FROM AUTHOR]