학술논문

Matrix Gla protein T-138C polymorphism is associated with carotid intima media thickness and predicts mortality in patients with diabetic nephropathy.
Document Type
Journal Article
Source
Journal of Diabetes & its Complications. Oct2017, Vol. 31 Issue 10, p1527-1532. 6p.
Subject
*Proteins
*Matrix Gla protein
*Diabetic cardiomyopathy
*Carotid intima-media thickness
*Kidney failure
*Mortality
*Cross-sectional method
*Arthritis Impact Measurement Scales
*Genetic polymorphisms
*Cardiovascular diseases
*Type 2 diabetes
*Severity of illness index
*Disease susceptibility
*Genes
*Survival analysis (Biometry)
*Calcium-binding proteins
*Genetic techniques
*Diabetic nephropathies
*Diabetic angiopathies
*Longitudinal method
*Disease complications
Cardiovascular disease related mortality
Language
ISSN
1056-8727
Abstract
Aims: We sought to determine the predictive value of Matrix Gla Protein MGP T-138C polymorphism in relation to all-cause mortality, cardiovascular mortality and cardiovascular events in patients with diabetic nephropathy (DN).Methods: MGP T-138C polymorphism was assessed in 40 diabetic patients without nephropathy and 118 patients at different stages of DN, including patients on hemodialysis. Measurement of carotid intima-media thickness (cIMT) was performed using real-time B-mode ultrasonography. Plasma levels of dephoshorylated uncarboxylated Matrix Gla Protein (dp-ucMGP) were determined in a subgroup of 67 patients by ELISA. Mortality and cardiovascular events were assessed during a 7year follow-up.Results: TT homozygotes for the MGP T-138C polymorphism had higher values of cIMT compared to combined TC and CC genotypes (P=0.006) whereas no association was observed between cIMT and dp-ucMGP levels. MGP T-138C polymorphism was a strong independent predictor of cIMT (P<0.0001), after adjustment for several well-known atherosclerosis risk factors. Patients with TT genotype presented a significantly higher all-cause and cardiovascular mortality risk compared to patients with TC and CC genotypes (P=0.01 and P=0.04 respectively), after adjustment for several traditional risk factors.Conclusions: MGP T-138C polymorphism is a strong and independent predictor of increased cIMT as well as all-cause and cardiovascular mortality in DN patients. [ABSTRACT FROM AUTHOR]