부산대학교 도서관

Introduction: Liver plays an important role in the metabolism of thyroid hormones. It also has a dominant role in the production and secretion of thyroid binding globulin. So, patients of cirrhosis of liver may be clinically euthyroid but thyroid hormones and thyroid binding globulin are altered. Low free T3 and free T4 along with increased reverse T3 (rT3) and decreased T3:T4 ratio are the common alterations observed in thyroid profile of such patients. Aim: To evaluate thyroid profile in patients with cirrhosis of liver; and correlation of thyroid profile with clinical and biochemical parameters of severity in patients with cirrhosis of liver. Materials and Methods: A cross-sectional observational study was conducted at a tertiary care hospital evaluating thyroid profile in 102 patients with cirrhosis of liver. results: Low free T3 and T4 was found in 72.5% and 26.47% of patients with cirrhosis of liver respectively. TSH towards the upper limit of normal range was observed in 52.3% of patients. Low free T3 and free T4 was found to be inversely related to the severity of liver disease. A significant correlation was also found between low free T3 levels, hyponatremia (p=0.004) and raised INR (p=0.038). Similarly, a significant correlation was also observed between low free T4 levels, serum bilirubin (p=0.049) and SGPT (p=0.008) levels. conclusion: Derangement in thyroid profile is common in patients with cirrhosis of liver. Low free T3 and T4 levels are associated with more severe liver injury and so may be used for prognostication in patients with cirrhosis of liver. [ABSTRACT FROM AUTHOR]