학술논문
Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.
Document Type
Article
Source
Subject
*AUTOPSY
*BRAIN diseases
*BRAIN banks
*POSTSYNAPTIC potential
*MORGUES
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Language
ISSN
2045-2322
Abstract
The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks. [ABSTRACT FROM AUTHOR]