학술논문
Synthesis and biological evaluation of thiazolo and imidazo N-(4-nitrophenyl)-7-methyl-5-aryl-pyrimidine-6 carboxamide derivatives.
Document Type
Article
Source
Subject
*ORGANIC synthesis
*PYRIMIDINES
*CHEMICAL derivatives
*ASPERGILLUS niger
*BACILLUS subtilis
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Language
ISSN
0922-6168
Abstract
Two new series of thiazolo and imidazo N-(4-nitrophenyl)-7-methyl-5-aryl-pyrimidine-6 carboxamide derivatives were synthesized. All the synthesized compounds were evaluated for their antimicrobial activity against Gram-positive bacteria: Staphylococcus aureus MTCC 3160, Bacillus subtilis MTCC 441, Gram-negative bacterium: Escherichia coli MTCC 443 and antifungal activity against Candida albicans MTCC 227 and Aspergillus niger MTCC 281 and free radical scavenging activity. Compound 7e was found the most active antimicrobial comparable to standards taken. Compounds 7a, 7c, 9a, and 9d also showed significant antibacterial and antifungal activity. Further, compounds 7f, 9d, and 9h showed significant antioxidant activity with IC comparable with the standard compound. The synthesized compounds were confirmed for their structure by means of various spectrometric techniques like IR, H NMR, mass, and elemental analysis. [ABSTRACT FROM AUTHOR]