학술논문
Impact of reactive oxygen species generation on Helicobacter pylori -related extragastric diseases: a hypothesis.
Document Type
Article
Author
Kountouras, Jannis; Boziki, Marina; Polyzos, Stergios A.; Katsinelos, Panagiotis; Gavalas, Emmanouel; Zeglinas, Christos; Tzivras, Dimitri; Romiopoulos, Iordanis; Giorgakis, Nikolaos; Anastasiadou, Kyriaki; Vardaka, Elizabeth; Kountouras, Constantinos; Kazakos, Evangelos; Xiromerisiou, Georgia; Dardiotis, Efthimios; Deretzi, Georgia
Source
Subject
*HELICOBACTER pylori
*REACTIVE oxygen species
*CARCINOGENESIS
*GASTRIC diseases
*MULTIPLE sclerosis
*GLAUCOMA
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Language
ISSN
1071-5762
Abstract
Helicobacter pylori(H. pylori) induces reactive oxygen species (ROS) production that contribute to pathogenesis of a variety ofH. pylori-related gastric diseases, as shown in animal and human studies.Helicobacter pyloriinfection is also associated with variety of systemic extragastric diseases in whichH. pylori-related ROS production might also be involved in the pathogenesis of these systemic conditions. We proposed thatHp-related ROS may play a crucial role in the pathophysiology ofHp-related systemic diseases including Alzheimer’s disease, multiple sclerosis, glaucoma and other relative neurodegenerative diseases, thereby suggesting introduction of relative ROS scavengers as therapeutic strategies against these diseases which are among the leading causes of disability and are associated with a large public health global burden. Moreover, we postulated thatH. pylori-related ROS might also be involved in the pathogenesis of extragastric common malignancies, thereby suggesting thatH. pylorieradication might inhibit the development or delay the progression of aforementioned diseases. However, large-scale future studies are warranted to elucidate the proposed pathophysiological mechanisms, includingH. pylori-related ROS, involved inH. pylori-associated systemic and malignant conditions. [ABSTRACT FROM AUTHOR]