학술논문
PSPC1: a contextual determinant of tumor progression.
Document Type
Opinion
Author
Source
Subject
*PROTEIN-tyrosine kinases
*CANCER invasiveness
*TUMOR suppressor genes
*NEOPLASTIC cell transformation
*METASTASIS
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Language
ISSN
2372-3556
Abstract
Protein-tyrosine kinase 6 (PTK6) sequestrated by its substrate paraspeckle component 1 (PSPC1) in nucleus is a tumor suppressor. PSPC1 functions as a contextual determinant of oncogenic subcellular translocations to synergize PSPC1/β-catenin and PTK6 tumorigenesis. Besides, PSPC1 C-terminal interacting domain (PSPC1-CT131), a dual inhibitor of PSPC1 and PTK6, suppresses cancer progression. [ABSTRACT FROM AUTHOR]