학술논문

Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the....
Document Type
Article
Source
Proceedings of the National Academy of Sciences of the United States of America. 06/05/2001, Vol. 98 Issue 12, p6865. 6p. 8 Color Photographs, 4 Diagrams, 12 Graphs.
Subject
*GLUCOCORTICOID receptors
*GENETIC regulation
*NF-kappa B
Language
ISSN
0027-8424
Abstract
Examines the regulation of human glucocorticoid receptor (hGR) gene expression by proinflammatory cytokines. Accumulation of dominant negative beta isoform; Function of NF-kappaB and glucocorticoid receptor (GR); Development of glucocorticoid resistance due to GRbeta protein expression.