부산대학교 도서관

Background: Globally, extensive research is being conducted for assessing the hyperlipidemia role in subjects of chronic kidney disease including in India according to the lipid nephrotoxicity hypothesis. Aim: The present retrospective clinical study was conducted to assess the correlation between the incidence of chronic kidney disease and dyslipidemia in Indian subjects. Methods: The present retrospective clinical study collected and assessed clinical data from medical records of subjects with no overt kidney disease. The included study subjects were divided into 4 groups based on low-density lipoprotein and total cholesterol levels. The collected data were subjected to statistical evaluation to assess the correlation between chronic kidney disease and blood lipid profile. Results: Lowest HDL-C value and highest HDL-C values were seen for the highest cholesterol group with a value of >5.40mmol/l (p<0.001). BUN and FPG values were lowest for cholesterol value of ≤4.20 mmol/l and highest for cholesterol range of >5.40mmol/l with p<0.001. SUA and hypertension values were significantly highest for high cholesterol values compared to low cholesterol values with p<0.001. Incidence of new chronic kidney disease (CKD) was highest in the age of >60 years with 8.08% (n=24) subjects followed by 3.93% (n=21) for >40-≤60 years, and least in 1.93% (n=9) subjects in ≤40 years. Incidence of new chronic kidney disease events was higher in the high cholesterol group with an incidence of 8.07% (n=26) subjects compared to the low cholesterol group with 1.82% (n=6) subjects Conclusion: The present study concludes that high total cholesterol, LDL, and triglyceride levels have an independent association with increased chances of declined eGFR (estimated glomerular filtration) rate and chronic kidney disease development. [ABSTRACT FROM AUTHOR]