학술논문
Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial.
Document Type
Article
Author
Brady, Lauren; Hayes, Brian; Sheill, Gráinne; Baird, Anne-Marie; Guinan, Emer; Stanfill, Bryan; Vlajnic, Tatjana; Casey, Orla; Murphy, Verena; Greene, John; Allott, Emma H.; Hussey, Juliette; Cahill, Fidelma; Van Hemelrijck, Mieke; Peat, Nicola; Mucci, Lorelei; Cunningham, Moya; Grogan, Liam; Lynch, Thomas; Manecksha, Rustom P.
Source
Subject
*RANDOMIZED controlled trials
*PROSTATE cancer patients
*ARM exercises
*CANCER cells
*EXERCISE
*PLATELET count
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Language
ISSN
1932-6203
Abstract
Background: Circulating tumour cells (CTCs) represent a morphologically distinct subset of cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine the effectiveness of a structured exercise programme in modulating levels of CTCs and platelet cloaking in patients with metastatic prostate cancer. Methods: Participants (n = 61) were randomised into either standard care (control) or exercise arms. Whole blood was collected for all participants at baseline (T0), three months (T3) and six months (T6), and analysed for the presence of CTCs, CTC clusters and platelet cloaking. CTC data was correlated with clinico-pathological information. Results: Changes in CTC number were observed within group over time, however no significant difference in CTC number was observed between groups over time. Platelet cloaking was identified in 29.5% of participants. A positive correlation between CTC number and white cell count (WCC) was observed (p = 0.0001), in addition to a positive relationship between CTC clusters and PSA levels (p = 0.0393). Conclusion: The presence of platelet cloaking has been observed in this patient population for the first time, in addition to a significant correlation between CTC number and WCC. Trial registration: ClincalTrials.gov identifier NCT02453139. [ABSTRACT FROM AUTHOR]