학술논문
Synchrotron X-ray diffraction study of the structure of oral stratum corneum model lipid membranes.
Document Type
Article
Author
Source
Subject
*BILAYER lipid membranes
*SYNCHROTRON radiation
*X-ray diffraction
*LIQUID crystals
*TERNARY system
*HIGH temperatures
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Language
ISSN
1063-7745
Abstract
Membranes modeling the lipid fraction of the mucous membrane of the human oral cavity have been studied by X-ray synchrotron diffraction. Ternary systems, composed of a mixture of sphingomyelin, dipalmitoylphosphatidylcholine, and dipalmitoylphosphatidylethanolamine with component weight ratios of 1: 2: 2 and 1: 2: 1, have lamellar structures in the gel phase at the physiological temperature (37°C). An inverted hexagonal phase is formed in the system with 40% dipalmitoylphosphatidylethanolamine in the temperature range of 60-70°C. This phase coexists with the liquid-crystalline lamellar phase in a narrow temperature range and completely surpresses the lamellar phase with an increase in temperature to 80°C. Multi-component oral stratum corneum membranes are characterized by several lamellar phases at 20-37°C and the coexistence of one or several lamellar phases with inverted hexagonal phase at 80-90°C. [ABSTRACT FROM AUTHOR]