학술논문
Synergetic copper/zinc catalysis: synthesis of aryl/heteroaryl-fused 1H-pyrrolo[3,2-c]pyridines.
Document Type
Article
Author
Source
Subject
*ZINC
*CATALYSIS
*ANNULATION
*RING formation (Chemistry)
*PYRIDINE
*COPPER
*ZINC catalysts
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Language
ISSN
1359-7345
Abstract
Scaffolds having a 1H-pyrrolo[3,2-c]pyridine core show significant biological activity. Herein, we report a synergetic copper/zinc-catalyzed one-step annulation reaction of 2-amino (hetero)arylnitriles with ynamide-derived buta-1,3-diynes to deliver 1H-pyrrolo[3,2-c]quinoline-2,4-diamine derivatives in moderate to good yields. The annulation reaction follows a double cyclization pathway. The gram-scale synthesis of 1H-pyrrolo[3,2-c]quinoline-2,4-diamine proves the practicality of this protocol. [ABSTRACT FROM AUTHOR]