학술논문
Two new anti-inflammatory trachylobane diterpenoids from Euphorbia atoto.
Document Type
Article
Author
Source
Subject
*ANTI-inflammatory agents
*PLANT anatomy
*BIOLOGICAL models
*IN vitro studies
*MACROPHAGES
*NUCLEAR magnetic resonance spectroscopy
*RESEARCH funding
*HYDROCARBONS
*PLANT extracts
*CELL lines
*QUERCETIN
*MICE
*ANIMAL experimentation
*ELECTROSPRAY ionization mass spectrometry
*MOLECULAR structure
*CHROMATOGRAPHIC analysis
*PHARMACODYNAMICS
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Language
ISSN
1028-6020
Abstract
Two new rare trachylobane euphoratones A-B (1-2), together with five known diterpenoids (compounds 3-7), were isolated from the aerial parts of Euphorbia atoto. Their structures were unambiguously elucidated through HRESIMS, 1D and 2D NMR spectral analysis. Compounds 1, 3, 4 and 7 showed weak anti-inflammatory activities (IC50 77.49 ± 6.34, 41.61 ± 14.49, 16.00 ± 1.71 and 33.41 ± 4.52 μM, respectively), compared to the positive control quercetin (IC50 15.23 ± 0.65 μM). [ABSTRACT FROM AUTHOR]