부산대학교 도서관

To estimate the prevalence of recent infection (RI) among people newly diagnosed with HIV in Spain using a representative sample collected by the AIDS Research Network cohort (CoRIS) during 2015–2016. Stratified sampling of CoRIS data was used with proportional allocation by mode of transmission of new HIV diagnoses notified to National Surveillance System. Samples used were from patients in the CoRIS cohort with available stored plasma collected within 6 months after diagnosis. Weighted methods were used to estimate the prevalence of RI and multivariate logistic regression models were used to determine associated factors. Of the 669 individuals included, 55.1% were men who had sex with men (MSM), 24.6% were heterosexual, and 20.3% were non-MSM non-heterosexual. The weighted prevalence of RI was 11.8% (95% Confidence interval [CI] 9.4–14.8%) overall, 15.5% (12.2–19.4%) among MSM, 6.3% (3.9–10.0%) among heterosexual, and 8.6% (3.2–20.9%) in non-MSM non-heterosexual persons. Factors associated with prevalence of RI were: MSM (OR 2.05; 95% CI 1.02–4.14) vs. heterosexual, being Spanish (OR 2.92; 1.36–6.26) or European (OR 3.42; 1.28–9.13) vs. Latin American, having a secondary or higher education level (OR 3.08; 0.95–1.00) vs. primary, and having a CD4 count of 350–499 (OR 3.26; 1.46–7.30) or >500 (OR 6.26; 2.92–13.39) vs. <350 cells/mm3. In the absence of direct data from surveillance systems, the use of cohort data is a very valuable option for identifying the prevalence of RI at national level. This is the first nationwide study carried out in Spain to determine the prevalence of RI using an avidity assay. [ABSTRACT FROM AUTHOR]