학술논문
Etiology of Diarrhea Among Hospitalized Children in Blantyre, Malawi, Following Rotavirus Vaccine Introduction: A Case-Control Study.
Document Type
Journal Article
Author
Source
Subject
*ROTAVIRUS vaccines
*ETIOLOGY of diseases
*HOSPITAL care of children
*SHIGELLOSIS
*DIARRHEA
*CASE-control method
*COMPARATIVE studies
*CRYPTOSPORIDIOSIS
*CRYPTOSPORIDIUM
*ESCHERICHIA coli
*FECES
*GASTROENTERITIS
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*RETROVIRUS diseases
*ROTAVIRUSES
*EVALUATION research
*DISEASE complications
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Language
ISSN
0022-1899
Abstract
Despite rotavirus vaccination, diarrhea remains a leading cause of child mortality. We collected stool specimens from 684 children <5 years of age hospitalized with diarrhea (cases) and 527 asymptomatic community controls for 4 years after rotavirus vaccine introduction in Malawi. Specimens were tested for 29 pathogens, using polymerase chain reaction analysis. Three or more pathogens were detected in 71% of cases and 48% of controls. Pathogens significantly associated with diarrhea included rotavirus (in 34.7% of cases and 1.5% of controls), enteric adenovirus (in 29.1% and 2.7%, respectively), Cryptosporidium (in 27.8% and 8.2%, respectively), heat-stable enterotoxin-producing Escherichia coli (in 21.2% and 8.5%, respectively), typical enteropathogenic E. coli (in 18.0% and 8.3%, respectively), and Shigella/enteroinvasive E. coli (in 15.8% and 5.7%, respectively). Additional interventions are required to prevent diarrhea due to rotavirus and other common causal pathogens. [ABSTRACT FROM AUTHOR]