부산대학교 도서관

The long-term success of lung transplantation ( LT) is limited by chronic lung allograft dysfunction ( CLAD). Different phenotypes of CLAD have been described, such as bronchiolitis obliterans syndrome ( BOS) and restrictive allograft syndrome ( RAS). The purpose of this study was to investigate the levels of cytokines and chemokines in bronchoalveolar lavage fluid ( BALF) as markers of these CLAD phenotypes. BALF was collected from 51 recipients who underwent (bilateral and unilateral) LT. The study population was divided into three groups: stable ( ST), BOS, and RAS. Levels of interleukin ( IL)-4, IL-5, IL-6, IL-10, IL-13, tumor necrosis factor alpha ( TNF-α), interferon-gamma ( IFN-γ), and granulocyte-macrophage colony-stimulating factor ( GM- CSF) were measured using the multiplex technology. BALF neutrophilia medians were higher in BOS (38%) and RAS (30%) than in ST (8%) ( P=.008; P=.012). Regarding BALF cytokines, BOS and RAS patients showed higher levels of INF -γ than ST ( P=.02; P=.008). Only IL-5 presented significant differences between BOS and RAS ( P=.001). BALF neutrophilia is as a marker for both CLAD phenotypes, BOS and RAS, and IL-5 seems to be a potential biomarker for the RAS phenotype. [ABSTRACT FROM AUTHOR]