학술논문
The Pharmacological Potential of Adenosine A 2A Receptor Antagonists for Treating Parkinson's Disease.
Document Type
Article
Author
Source
Subject
*ADENOSINES
*PARKINSON'S disease
*
Language
ISSN
1420-3049
Abstract
The adenosine A2A receptor subtype is recognized as a non-dopaminergic pharmacological target for the treatment of neurodegenerative disorders, notably Parkinson's disease (PD). The selective A2A receptor antagonist istradefylline is approved in the US and Japan as an adjunctive treatment to levodopa/decarboxylase inhibitors in adults with PD experiencing OFF episodes or a wearing-off phenomenon; however, the full potential of this drug class remains to be explored. In this article, we review the pharmacology of adenosine A2A receptor antagonists from the perspective of the treatment of both motor and non-motor symptoms of PD and their potential for disease modification. [ABSTRACT FROM AUTHOR]